Emerging Metabolic Therapies in Pulmonary Arterial Hypertension
نویسندگان
چکیده
منابع مشابه
Emerging Metabolic Therapies in Pulmonary Arterial Hypertension
Pulmonary hypertension (PH) is an enigmatic vascular disorder characterized by pulmonary vascular remodeling and increased pulmonary vascular resistance, ultimately resulting in pressure overload, dysfunction, and failure of the right ventricle. Current medications for PH do not reverse or prevent disease progression, and current diagnostic strategies are suboptimal for detecting early-stage di...
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Pulmonary arterial hypertension (PAH) is a fatal disease associated with vasoconstriction and vascular remodelling. There are three well-known pathways that contribute to the pathogenesis of PAH: endothelin, nitric oxide and prostacyclin. Treatments targeting these pathways are well established in clinical practice, such as endothelin receptor antagonists, phosphodiesterase type-5 inhibitors an...
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Numerous molecular abnormalities have been described in pulmonary arterial hypertension (PAH), complicating the translation of candidate therapies to patients because, typically, 1 treatment addresses only 1 abnormality. The realization that in addition to pulmonary artery vascular cells, other tissues and cells are involved in the syndrome of PAH (eg, immune cells, right ventricular cardiomyoc...
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Pulmonary arterial hypertension (PAH) is a rare, progressive disorder that leads to an inexorable rise in pulmonary vascular resistance, ultimately resulting in right ventricular failure and death if left untreated. Currently available pulmonary vasoremodeling therapy has significantly improved morbidity and mortality in PAH. However, 3-year mortality in PAH is still higher than in many other c...
متن کاملTargeted oral therapies in the treatment of pulmonary arterial hypertension.
Recent advances in our understanding of the pathophysiology of pulmonary arterial hypertension (PAH) have led to the US FDA's approval of eight drugs for its treatment. Although guidelines for the use of PAH therapies are available and regularly updated, there is a lack of information on how these agents differ and what characteristics may enable one agent to be of greater relative clinical uti...
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ژورنال
عنوان ژورنال: Journal of Clinical Medicine
سال: 2017
ISSN: 2077-0383
DOI: 10.3390/jcm6040043